Belz and colleagues show that Peyer’s patch M cells are required for ILC3 localization, proliferation and IL-22 production within the dome epithelium.

Murphy and colleagues report that the transcriptional regulator ID2 promotes cDC1 fate specification by antagonizing E protein activity at E-boxes within the Zeb2 enhancer and establish the Zeb2 −165-kb enhancer as a pleiotropic enhancer.

Here, Brennan and colleagues report that chronic type 2 inflammation drives the differentiation of progenitor-like T helper 2 cells, distinct from acute and resting memory cells and with the capacity to sustain lung inflammation in the face of ongoing antigen exposure.

Here the authors create a syncytial chimeric antigen receptor (CAR) cell that fuses CAR macrophages with neutrophils, equipping these cells with the antitumor functions from both cell types.

HIV reservoir cells are traditionally considered invisible to host immune responses due to viral latency. This work challenges this view by demonstrating that HIV persistence during long-term antiretroviral therapy is strongly influenced by KIR2DL1-educated NK cells.

Kim and colleagues describe a population of monocyte-derived lung galectin-1⁺ myeloid cells that support the generation and maintenance of lung-resident memory CD8⁺ T cells following influenza virus infection.

Murphy and colleagues report that the transcriptional regulator ID2 promotes cDC1 fate specification by antagonizing E protein activity at E-boxes within the Zeb2 enhancer and establish the Zeb2 −165-kb enhancer as a pleiotropic enhancer.

Here, Brennan and colleagues report that chronic type 2 inflammation drives the differentiation of progenitor-like T helper 2 cells, distinct from acute and resting memory cells and with the capacity to sustain lung inflammation in the face of ongoing antigen exposure.

Here the authors create a syncytial chimeric antigen receptor (CAR) cell that fuses CAR macrophages with neutrophils, equipping these cells with the antitumor functions from both cell types.

Belz and colleagues show that Peyer’s patch M cells are required for ILC3 localization, proliferation and IL-22 production within the dome epithelium.

High-throughput, high-dimensional profiling technologies have transformed the ability to generate and test hypotheses of human immunology. Investment in infrastructure has catalyzed the expansion of human cohorts and data repositories and enabled opportunities to predict disease risk, promote early diagnosis and design interventions that promote health.

In the context of a Public Health Emergency of International Concern, such as the Bundibugyo virus outbreak, the research community requires rapid access to information to guide an effective response. Evidence mapping brings together the available knowledge in a field into a single, organized resource, enabling researchers to rapidly identify priorities, gaps and opportunities for action.