Scientist, Data Analysis & Bioinformatics

Salary Range:

$90,000.00 To $110,000.00 Annually

POSITION SUMMARY

The Scientist, Data Analysis & Bioinformatics, is responsible for analyzing both internal and external datasets to provide mechanistic insights into clinical response, deliver data analysis and interpretation in support of research programs, develop/validate analysis pipelines, perform modeling & simulation of biological processes and integrate internal data with public datasets to support internal decisions. This is a junior position that will report and will be mentored directly by the Vice President of Translational Research at Delcath. 

ESSENTIAL DUTIES & RESPONSIBILITIES include the following.

• Work collaboratively within the Translational Research group to analyze internally generated and publicly available high throughput (gene expression spatial biology, proteomics, radiology, etc.) datasets from preclinical & clinical studies to provide mechanistic insights on Delcath R&D programs.
• Analysis of biomarker data from pre-clinical & clinical samples in support of all R&D programs, including INDs and NDAs.
• Integrate biomarker data from investigator-initiated trials, Delcath sponsored trials, and public datasets to inform on mechanism of action and clinical response/resistance 
• Deliver data analysis and interpretation from internal studies to support patent filings
• Support external collaborations with data analysis capabilities
• Development and validation of analysis pipelines (for example gene expression, radiology & pathology) 
• Validate prognostic and predictive signatures from publicly available datasets
• Lead external communication efforts: posters, presentations, conferences, publications

SUPERVISORY RESPONSIBILITES

This position currently has no direct reports or supervisory responsibilities.

EDUCATION and/or EXPERIENCE

• PhD in bioinformatics, computational biology, data analysis or related field OR Masters with 4+ years of work experience

CORE AND DESIRED KNOWLEDGE & SKILLS

• Proven background in bioinformatics and/or data analysis working with complex datasets
• Self-driven and able to work in a fast-paced environment as an independent and collaborative team member
• Fluent in Linux and coding in Python and R
• Desired:
• Experience in modeling & simulation, computational image analysis, and/or machine learning
• Previous training or work experience in oncology or molecular biology
• Strong verbal and written communication skills 
• Experience with Matlab, Plateau or Spotfire

LANGUAGE SKILLS

Ability to read and interpret documents such as technical journals, safety rules, operating and maintenance instructions, and procedure manuals. Ability to write routine reports and correspondence. Ability to speak effectively with employees and outside organizations. 

MATHEMATICAL SKILLS

Ability to add, subtract, multiply, and divide in all units of measure, using whole numbers, common fractions, and decimals. Ability to compute rate, ratio, and percentage and create and/or interpret spreadsheets and graphs.

PHYSICAL DEMANDS 

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to sit. The employee is frequently required to use hands to finger, handle, or feel and reach with hands and arms; and is subject to repetitive motions of the wrists, hands, and/or fingers. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception, and ability to adjust focus.

WORK ENVIRONMENT 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. While performing the duties of this job, the employee is occasionally exposed to moving mechanical parts, heat, airborne particles, moderate noise and outside weather conditions.