Until

Rarely do you get to experience a true full-circle moment like this. Gerald Brandacher was my PhD advisor—the person who pushed me to think beyond what’s been done and focus on what’s possible in transplantation. Now, we get to build the future of organ preservation together at Until This work has always been about one thing: turning time from a limitation into a tool. And there’s no one better to help lead that mission. Energized about what is next! #Transplantation #OrganPreservation #Biotech #Innovation #Until

We’re excited to welcome Dr. Gerald Brandacher as our Chief Medical Officer at Until Labs! 👏 🎉 A pioneer in transplant surgery, Dr. Brandacher brings decades of leadership at the forefront of transplant technology. His work has focused on extending organ viability and preserving complex biological function beyond historical surgical time limits, including recent advances in sub-zero organ preservation that dramatically expand how long organs can remain viable outside the body. He contributed to the first bilateral hand and forearm transplants in the U.S. while at UPMC, and later served on the core surgical team for the first total male genital transplant at Johns Hopkins. His work has helped redefine what can be restored to the human body through vascularized composite allotransplantation. We’re thrilled to bring his pioneering spirit to the next frontier of transplantation: reversible cryopreservation, making time a tool in medicine.

"We distill our challenge to a single, elegant first principle: pause molecular motion in every organelle, in every cell, in every tissue of a human organ, then resume it." Read more about our work at the link below, and check out our open roles. We're hiring.

We're hiring at Until, come join our team!

Today we’re publishing Glass, Not Ice. It’s a detailed walkthrough of what a reversible cryopreservation protocol could look like, and why we're building this technology first for patients who need an organ transplant. Check it out here 👉 https://lnkd.in/gswTb3yW

We partnered with the exceptional team at basement.studio to create a new brand and website for Until. We’re so excited to finally share what we’ve been working on: ✨ https://www.untillabs.com/ ✨ For our homepage, we hoped show that reversible cryopreservation is, at its core, a molecular physics problem. basement.studio nailed this 💪 You can zoom into the molecular landscape of a person, observe the scene as the temperature gets cooler and motion slows to a complete halt. Ice is the enemy. Everything we engineer is in service of preventing it. And lastly, the whole point of this endeavor, is to have more time with our loved ones, more peaceful afternoons, more picnics in the sun, more precious moments. We're building for people we love. We also wanted our new site to highlight the people making reversible cryopreservation real. Our team is full of rockstar scientists and engineers and operational magicians. Their commitment, their late-night sprints, their creative investment, and rigor are what moves this technology forward. To our team, thank you ❤️ They are working at one of the most ambitious intersections of biology, physics, and hardware. If that sounds like your kind of challenge, we’re hiring. https://lnkd.in/gzi8Jav3 We couldn't have asked for a better collaborator than basement.studio. They developed a brand that feels warm, captures our soul, and celebrates our incredible team, Thank you so much! :) <3 

We recently partnered with the remarkable folks at Card79 to create visual walk-through of what reversibly cryopreserving a kidney might look like. What you’re watching: A donated kidney is perfused with cryoprotectants, replacing the water in its cells, and nanoparticles, for later rewarming. The organ is cooled below –130°C, pausing molecular motion, the organ can safely stay at this temperature indefinitely, until the right recipient is ready. This rendition of time passing as the organ stays safely preserved in the a biobank is our favorite scene ❤️ When a perfect match is found, the organ is gently rewarmed in an alternating magnetic field coil, cryoprotectants and nanoparticles are flushed out, blood is re-perfused, health and vitals are assessed, and the organ is ready for transplant, set to save a life. Until’s mission is simple: Pause molecular motion to give patients more time. We aim to extend viable preservation from hours to weeks — until matching, transport, and transplant are no longer a race against the clock. Card79 went above and beyond. Thank you for bringing rigor, care, and beauty to this collaboration. You took an incredibly complex process and created a visual distillation that is intuitive and clear 👏

Until is coming to New York! Come hear about our progress and chat with members of our team on Nov 4th 🌆

Check out our CEO Laura Deming's conversation with Mario Gabriele on The Generalist Podcast! Their discussion traverses many things: the legitimization of stigmatized research areas in health, why she founded Until, our approach to building reversible cryopreservation tech for donor organs, meeting our CSO and co-founder Hunter Davis, embracing weirdness, and much more 🙂 It is a deep and nuanced dive. Thank you Mario for such thoughtful questions and explorations 💕

We’ve raised $100M+ to date, we are developing reversible cryopreservation for patients in need of donor organs, and we are hiring 🫀🎉🚀 We’ve closed a $58M Series A, led by Founders Fund with Lux Capital and Field Ventures joining, to support development of an organ cryopreservation product. In the near term, this will help transplant patients and surgeons access the organs they need. This also serves as an important step in our long-term roadmap to medical hibernation. The timing of an organ donation is critical. Most organs remain viable for only hours after procurement, 4–12 for hearts, lungs, and livers; 24–36 for kidneys. That narrow window means patients live tethered to hospitals, and thousands of organs are lost every year due to logistics.  We’re changing that. We’re building reversible cryopreservation so that every donated organ with the potential to save a life, can. We’re building the whole stack: • novel cryoprotectants • custom cooling & rewarming hardware • perfusion & surgical protocols • molecular modeling engines • magnetic rewarming systems We started in neural slices. Now we’re preserving preclinical model organs. This work lays the foundations for our long term vision of whole-body medical hibernation technology. You can read our updated Problem Statement and Roadmap here: https://lnkd.in/gV9cqiUS 👀 Over the last year, we’ve built a CPA discovery engine, designed a custom electromagnet, and iterated cooling protocols to reduce time-to-glass. We’re now testing in large animal organs — optimizing for quality post cryopreservation. Our lab traverses disciplines, a single day at Until might span simulating molecular dynamics, running benchtop assays with high throughput liquid-handling robots, mapping vasculature, exploring the physics of high voltage electromagnets, or designing topologically optimized heat exchangers. Our perfusion experts and molecular biologists work in close collaboration with our hardware engineers and physicists. The team is diverse by design because the problem is diverse by nature. We move between theory and practice, from first principles to functional prototypes. If you’re energized by deep technical problems, mission-driven science, and rendering technology to extend human well-being, join us. And of course, the fundraise would not have been possible without our incredible team, thank you ❤️